Specific Enzyme, a Protein Kinase, Found to Correlate with Neuronal Damage in Alzheimer’s

Specific Enzyme, a Protein Kinase, Found to Correlate with Neuronal Damage in Alzheimer’s
Increased activity of mutant forms of a specific enzyme, protein kinase Cα (PKCα), correlates with damage to neurons caused by the amyloid-beta protein in late-onset Alzheimer’s disease, researchers from the University of California, San Diego, School of Medicine and Harvard Medical School reported. The findings also suggest that drugs inhibiting the enzyme, unsuccessful in cancer clinical trials, might have therapeutic value in AD. The study, “Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer’s disease”, was published in Science Signalling. Plaque deposits of insoluble, aggregated amyloid β (Aβ) peptide i
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