Potential Alzheimer’s Vaccine Undergoing Pre-Clinical Trial Tests

Potential Alzheimer’s Vaccine Undergoing Pre-Clinical Trial Tests
Scientists have developed a novel form of vaccine targeting the two main proteins triggering Alzheimer's disease, amyloid-beta and tau protein. Researchers and physicians have seen an increase in Alzheimer's disease, with more than 7.5 million new cases diagnosed worldwide per year. There is an urgent but still unmet need for a vaccine and effective treatment for dementia, one of the most detrimental features of Alzheimer's disease. Researchers at Flinders University in Australia, collaborating with colleagues at the Institute of Molecular Medicine (IMM) and the University of California at Irvine (UCI), have designed a successful vaccine formulation that targets the abnormal beta-amyloid and tau proteins that signal Alzheimer's disease. The study, “Alzheimer's disease AdvaxCpG- adjuvanted MultiTEP-based dual and single vaccines induce high-titer antibodies against various forms of tau and Aβ pathological molecules, was published in the journal Scientific Reports. "If we are successful in preclinical trials, in three to five years, we could be well on the way to one of the most important developments in recent medical history," Professor Nikolai Petrovsky at Flinders University School of Medicine, and director of the South Australian vaccine research company Vaxine Pty, said in a press release. "Along with our rapidly aging populations, we now know that the explosion in type 2 diabetes in the West is likely to further dramatically fuel the p
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6 comments

  1. Jill Craner says:

    I have a strong history of AD on both sides of my family. I am a retired nurse at age 62. I would like to participate in the clinical trials for the vaccine. How can I do this in my area Springfield, Il?

    • Janet says:

      I found a trial (search for number NCT02579252) but it looks like it’s not available to healthy participants, only people with diagnosed Alzheimer’s disease.

    • Janet says:

      You may be eligible for nutrition intervention study at Rush in Chicago when you turn 65 for healthy people with family history of dementia. Or you can just try to follow that diet yourself. Search for NCT02817074

  2. William Peterson says:

    My wife was diagnosed with Alzheimer’s disease last year. Her father also died of Alzheimer’s disease. She would like to participate in clinical trials of the vaccine. We live in Phoenix, AZ.

  3. My Grand father had Alzheimer. My Father just died from it. I am 56 and i am hoping i do not have it. I would like to be part of your trails. I also have two brothers that may also have it. Please help us.

  4. TRACY says:

    Is this trial really just for someone that has been diagnosed??? AD runs really bad on my dad’s sign. His sister died of it, 1 of her daughters before 60 and another is in a home now with it and she is about 63. Not sure if I dad would have gotten it, he died of Cancer at 66 but my sister swears he was getting it. My mom died last year at 81 with it. I have heard her brother is starting to get it. SO with that being said, me and my 4 siblings are more than likely going to get it. I would be interested in the study for myself if that is possible.

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