Tau Antibodies May Best Treat Alzheimer’s by Avoiding an Inflammatory Trigger

Tau Antibodies May Best Treat Alzheimer’s by Avoiding an Inflammatory Trigger
Researchers at Genentech discovered that antibodies against tau — a protein creating toxic tangles inside nerve cells of people with Alzheimer's disease — protect from tau toxicity only when antibodies don’t engage inflammation-triggering microglial cells to get rid of the protein. The findings, published in the journal Cell Reports under the title "Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement," are likely to inform future attempts to develop anti-tau therapies for Alzheimer's, as well as a multitude of ot
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