ALZ-801 Works Against Alzheimer’s by Preventing Protein Component Clumping, Study Reports

ALZ-801 Works Against Alzheimer’s by Preventing Protein Component Clumping, Study Reports
The Alzheimer's therapy ALZ-801 works by preventing protein components from clumping together to trigger the amyloid plaque accumulation in the brain that causes the disease, researchers say. Disease-modifying drugs for Alzheimer's and other neurodegenerative diseases could evolve from the findings, the team said. Researchers knew that tramiprosate, the active ingredient in Alzheon's ALZ-801, inhibited the beta amyloid protein that causes amyloid plaque, but they didn't know how. Now they know. The study, “Elucidating the Aβ42 Anti-Aggregation Mechanism of Action of Tramiprosate in Alzheimer’s Disease: Integrating Molecular Analytical Methods, Pharmacokinetic and Clinical Data,” were published in the journal CNS Drugs. Tramiprosate is a small-molecule therapy that was evaluated in Phase 3 clinical trials for Alzheimer's but failed to meet the study's main effectiveness goal. ALZ-801, which is being readied for a Phase 3 clinical trial, is an optimized version of tramiprosate. It has a better drug-property profile and better metabolic stability -- or ability to remain in the body -- and patients tolerate it better. Researchers discovered that tramiprosate works by enveloping small protein components known as amyloid peptides. This prevents the peptides from clumping together to form the beta amyloid oligomers known to promote Alzheimer's. "While we have recognized for nearly four decades that amyloid plaques are the hallmark of Alzheimer's disease, the emerging insights are pointing to small protein aggregates
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3 comments

  1. Jack Beatrice says:

    Would like to participate in the clical trails for ALZ-801. My wife is 66 and was diagnosed two years ago.

    • Tim Bossie says:

      Jack, please talk with your doctor about the possibility of participating in this trial and if it is in your area.

  2. Dante J Marciani says:

    Very exciting work. The MOA of this small compound suggests the possibility of a multi-prong approach to deal with amyloid toxicity. Inhibiting the formation of toxic oligomers with ALZ-801, and using specific antibodies to neutralize the toxicity of those oligomers already present.

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