Link Between Lysosomes and Granulins in Brain Cells May Aid Understanding of Alzheimer’s

Link Between Lysosomes and Granulins in Brain Cells May Aid Understanding of Alzheimer’s
Researchers developed antibodies targeting a group of proteins called granulins, and discovered for the first time that they're important to the well-being of lysosomes, which are vital organelles linked to neurodegenerative diseases that include Alzheimer's disease (AD) and frontotemporal dementia (FTD). This discovery, by a research team at Emory University School of Medicine, may foster a better understanding of the mechanisms underlying Alzheimer's and similar diseases. The study “Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins That Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by GRN Mutations
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