Canola Oil Worsens Memory and Learning Ability of Mice with Alzheimer’s, Study Shows

Canola Oil Worsens Memory and Learning Ability of Mice with Alzheimer’s, Study Shows
Giving mice with Alzheimer's a canola oil-rich diet for six months led to their memory and learning ability worsening, a study reports. The research, “Effect of canola oil consumption on memory, synapse and neuropathology in the triple transgenic mouse model of Alzheimer’s disease,” was published in the journal Scientific Reports. Claims that the rapeseed extract canola oil is good for health, particularly the heart, has led to a jump in its consumption in recent years. But little research has been done on whether the claims are true. "Canola oil is appealing because it is less expensive than other vegetable oils, and it is advertised as being healthy," Dr. Domenico Praticò, an Alzheimer's expert at Temple University's Lewis Katz School of Medicine, said in a press release. "Very few studies, however, have examined that claim, especially in terms of the brain." Pratico's team used a mouse model of Alzheimer's to investigate canola's effect on the formation of two harmful brain structures — amyloid protein clumps and twisted masses of proteins known as neurofibrillary tangles. Scientists have connected the two with the nerve cell degeneration and memory loss in Alzheimer's. The mice displayed the human features of Alzheimer's, and their condition deteriorated with age. When they were six months old, researchers divided them into two groups. They fed one group a normal diet and the other a diet supplemented with a tablespoon of canola oil a
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  1. Niklas Reich says:

    It has to be noted that cheap canola oil has been used in this study (non-native / not cold-pressed)… Extraction under high heat destroys the health-beneficial poly-unsaturated fats in canola oil and creates harmful trans-saturated fatty acids. The same happens if any type of native oil is heated up to too high temperatures.

    The issue I see is that this was compared to higher quality (native) olive oil… They should have used native canola oil also.

  2. Hinrich Wrage says:

    A tablespoon of canola oil a day is allot of fat for small mouse! No human drinks a galon of canola oil every day!!! Too much of ANY fat is bad. Better compare against animal fat!!

  3. Hinrich Wrage says:

    It doesn’t make sense to compare mega-fat-dosage with a normal diet. ANY fat will show bad results in such setup. At least they could have tested a 3rd group fed with olive oil. THAN, and ONLY than you could make assumptions as Perlmutter did. There are MANY human trials on omega-3 and they show that NORMAL amounts of non-maritime-omega-3 REDUCES the risk of dementia and Alzheimer. [i.e. Neurology 2007; 69: 1921-1930; DeLorenze GN, et al. Arch Neurol. 2006 Apr;63(6):839-44.]. It can probably half the risk: Regular use of omega-3 rich oils was associated with a decreased risk of borderline significance for all cause dementia (HR 0.46, 95% CI 0.19 to 1.11). [Barberger-Gateau P, et al. Neurology. 2007 Nov;69(20):1921-30]

  4. Niklas Reich says:

    I agree with previous posts. Adding a high amount of fat in form of cheap oil turnes the mice’ diet into a high fat diet which is known to promote development of insulin resistance (a clear risk factor of AD) and inflammation, also appearing within and negatively affecting the brain.
    i.e. see:
    Maldonado-Ruiz, R., Montalvo-Martinez, L., Fuentes-Mera, L. & Camacho, A. (2017). Microglia activation due to obesity programs metabolic failure leading to type two diabetes. Nutrition & Diabetes, 7.

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