Gut Microbiome May Have Central Role in Alzheimer’s and Like Diseases, Study Argues

Gut Microbiome May Have Central Role in Alzheimer’s and Like Diseases, Study Argues
The gut microbiome is increasingly seen as a key player in serious and chronic neurodegenerative diseases like Alzheimer's and Parkinson's — for reasons that are being suggested and explained, but not quite named. Now, researchers propose a term — “mapranosis” — to capture the process by which amyloid proteins produced by certain gut microbes can modify the structure of amyloid proteins in the brain produced by neurons, leading to inflammation in the central nervous system. By giving it a name researchers hope to increase awareness of the gut-brain axis among clinicians and researchers alike, and spur greater investigation into it. "It is critical to define the ways in which gut bacteria and other organisms interact with the host to create disease, as there are many ways in which the microbiota may be altered to influence health," Robert P. Friedland, M.D, the study's lead author and a neurology professor at the University of Louisville, said in a press release. The term — proposed by Friedland and Matthew Chapman, a professor at the University of Michigan — defines the damage caused to proteins and the inflammation that follows by the natural community of microorganisms that reside in our gut. This community,  the so-called gut microbiome, is a diverse population of different bacteria, viruses, fungi, archaea and parasites. Certain members of the gut microbiome produce amyloid proteins similar to those produced by neurons. These microbiome-produced proteins have the capacity to alter the structure of the other proteins, increasing the inflammation associated with neurodegeneration. "
Subscribe or to access all post and page content.



    This information strongly supports the concept of prevention by vaccination. Yet, these vaccines cannot be of the classic type used for infectious diseases or cancer. They would need to be anti-inflammatory, which is not a small task, considering the scarcity of effective anti-inflammatory Th2 adjuvants. But, the goal should be achievable.

  2. Sean Kulyk says:

    To me this further demonstrates how far modern ‘civilised’ living has contributed to preventing us from reaching our true health ‘potential’, including mental health. Naturopath’s including Hippocrates have long espoused the importance of good gut health, with expressions like “health begins in the gut, and death begins in the gut”!

    NO surprise then that most traditional (and healthy) societies utilise variations of fermented foods, from Kefir, Kemchi, Sauerkraut, Miso, Waikame, and Natto, and that researchers have noted the longevity and good health, including mental health of these populations.
    Indeed populations that have the widest range of microbiome microiota have been shown to be the healthiest, and have very significantly less of the modern diseases / conditions including Alzheimers.
    For sure there are of course other positive contributory factors including :
    (a) more direct contact with nature and therefore exposure to a wider range of microbiota
    (b) consumption of a substantial amount of raw vegetables (i.e. again with intact micro flora)
    (c) far less stress than we do today; very important as continual/prolonged stress (courtesy of elevated cortisol) has been shown to negatively affect our microbiome, and indeed cortisol is destructive to tissue including brain tissue; whereas positive emotions have been shown to have a positive effect on the microbiome, and indeed brain health etc.

    When we compare such microbiota exposure with our own, it is clear that we have much less contact with the many beneficial bacteria that we so clearly need in so many ways; that and the history of INNAPROPRIATE / OVERUSE of (microbiota disrupting) antibiotics in the last 40 + years, it is no surprise that digestive problems are rife in modern society, as is the rise in dementia’s including Alzheimers. For the record; I have no problem with appropriate use of antibiotics (for which they we e designed) i.e. in acute bacterial infections; these have saved millions of lives – however more use / exposure clearly does not ultimately help our micrbiome.

    Even those who don’t utilise antibiotics via medical treatments, are also recipients of antibiotics via food from animals that have been pumped with antibiotics every week of their lives. Indeed from animals that are the product of ‘factory farming’, and are regularly stressed compared to their ‘free range’ relatives.
    All of this reiterates why I feel we have to be proactive and indeed more ‘holistic’ in our approach to health; and i am afraid to say that simply will not be solved by yet another vaccination, with or without adjuvants!

    In summary, as a natural medicine practitioner of 26 years, it seems to me (and I would guess others such as Dr David Perlmutter MD) that ultimately in the greater scheme of things Alzheimers is also a ‘symptom’ of a society that has ‘lost its way’ and is suffering from the effects of ‘Nature Deficit Disorder’ and therefore end up with a microbiome with a very limited and unbalanced range of microbiota with it’s consequent effects including on our brains.

    Sean Kulyk
    Homeopath, registered Kinesiologist & Spinal Touch practitioner (UK)

Leave a Comment

Your email address will not be published. Required fields are marked *