Chronic Exposure to Caffeine Worsened Symptoms in Alzheimer’s Mouse Model

Long-term exposure to caffeine worsens Alzheimer's disease symptoms, a new mouse study shows. The study “Long-term Treatment with Low-Dose Caffeine Worsens BPSD-Like Profile in 3xTg-AD Mice Model of Alzheimer’s Disease and Affects Mice with Normal Aging” was published in the journal Frontiers in Pharmacology. Alzheimer’s disease is characterized by memory problems, but also by neuropsychiatric symptoms, collectively known as Behavioral and Psychological Symptoms of Dementia (BPSD). Those symptoms may include depression, apathy, hallucinations, delusions, agitation, aggression, and sleep disturbances. Consumption of coffee/caffeine recently has been suggested as a preventive strategy for dementia in Alzheimer's disease and aging-related decay due to its inhibitory activity over adenosine A2A receptors, which show an abnormal expression and function in aging and related diseases. In fact, according to researchers, “at the experimental level, long-term caffeine treatment has been demonstrated to ameliorate [improve] cognitive impairment in animal models of Alzheimer disease.” However, recent research suggests that once the neuropsychiatric symptoms are set, caffeine may have the opposite effect. "The mice develop Alzheimer's disease in a very close manner to the human patients with early-onset form of the disease. They not only exhibit the typical cognitive problems but also a number of BPSD-like symptoms, so it is a valuable model to address whether the benefits of caffeine will be able to compensate its putative [pre
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