Chronic Inflammation May Underlie Higher Alzheimer’s Risk in ApoE4 Carriers, Study Shows

Chronic Inflammation May Underlie Higher Alzheimer’s Risk in ApoE4 Carriers, Study Shows
Chronic, low-level inflammation enhances the risk of Alzheimer's disease among ApoE4 gene carriers, the major genetic risk factor for the late-onset form of the disorder, a study shows. The study, “Association of Chronic Low-grade Inflammation With Risk of Alzheimer Disease in ApoE4 Carriers,” was published in the journal JAMA Network Open. People who carry two copies of the apolipoprotein E4 (ApoE4) gene have a significantly higher risk of developing Alzheimer's disease after the age of 65 than the rest of the population. However, not all of these carriers will develop Alzheimer's, even those who are 90 or older. Researchers at the Boston University School of Medicine (BUSM) hypothesized that a complex interaction of genetic vulnerabilities with environmental risk factors may influence the risk of developing Alzheimer's disease among certain ApoE4 carriers. "Finding out what mediating factors for ApoE4 increase AD risk is important for developing intervention and prevention of the disease," Wendy Qiu, MD, PhD, associate professor at BUSM and the study's lead author, said in a press release. Chronic inflammation is common among the elderly, leading researchers to hypothesize that it may influence the risk of Alzheimer's disease.
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