Alzheimer’s Patient is First to Get Focused Ultrasound Treatment

Alzheimer’s Patient is First to Get Focused Ultrasound Treatment
  A new treatment using focused ultrasound to treat early-stage Alzheimer’s disease was successfully administered to a patient. The treatment, which involves incisionless surgery and no pharmaceuticals, is part of a worldwide Phase 2 trial. The trial (NCT03671889) is underway and recruiting up to 10 participants — men or women 50-85 years old with probable Alzheimer's disease. It will be conducted at up to four sites in the United States. This clinical study is examining whether focused ultrasound diminishes the toxic protein aggregates and cognitive dysfunction that are hallmarks of Alzheimer’s disease. This type of non-invasive treatment involves the application of acoustic energy at low frequencies into distinct targets to induce blood-brain barrier (BBB) disruption in the regions of the brain affected by Alzheimer’s disease, such as the hippocampus. The BBB separates the brain from the bloodstream for protective reasons; however, the BBB limits the immune system, for immunotherapy, and many potentially effective pharmaceutical treatments from reaching diseased brain areas. During the summer of 2017, researchers at Sunnybrook Health Sciences Centre in Toronto reported the results of a Phase 1 clinical trial (NCT02986932) showing that they could safely open and reseal the BBB in six patients with early-sta
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3 comments

  1. Kare Dresang says:

    e Phase 2 trial. The trial (NCT03671889) is underway and recruiting up to 10 participants — men or women 50-85 years old with probable Alzheimer’s disease.
    How do you get on the list??

  2. Martin Corrick says:

    I am an Alzheimer’s patient, keen to participate in trials. Is the focused ultrasound technique being trialed anywhere in the UK?

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