APP Gene’s Diversity Holds Potential to Treat Alzheimer’s with HIV Therapies, Researchers Say

APP Gene’s Diversity Holds Potential to Treat Alzheimer’s with HIV Therapies, Researchers Say
Brain nerve cells of Alzheimer’s disease patients can produce thousands of variants of the APP gene, which codes for β-amyloid protein, a hallmark of the disease, researchers say. An enzyme important to the human immunodeficiency virus (HIV) is a key player in APP’s genetic diversity, supporting the potential for HIV antiretroviral therapies to treat Alzheimer's. "These findings may fundamentally change how we understand the brain and Alzheimer's disease," Jerold Chun, MD, PhD, professor and senior vice president of Neuroscience Drug Discovery at California's 
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