Gene That Makes Neurons Vulnerable to Abnormal Levels of Tau Protein Identified in Study

Gene That Makes Neurons Vulnerable to Abnormal Levels of Tau Protein Identified in Study
A study has identified the gene that explains why excitatory neurons — brain cells that excite their targets — are more vulnerable to accumulations of abnormal tau protein aggregates, which are implicated in Alzheimer’s disease. The research article, “A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology,” was published in the journal Nature Neuroscience. The accumulation of atypical protein aggregates called tau is a defining feature of Alzheimer’s disease and frontotemporal
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