Small Molecule Originally Developed to Treat Depression Improved Memory in Alzheimer’s Mouse Study

Small Molecule Originally Developed to Treat Depression Improved Memory in Alzheimer’s Mouse Study
A small molecule delivered orally for 56 days improved memory in mice carrying the ApoE4 gene, the most common genetic risk factor for Alzheimer’s disease. The molecule, called A03 and initially developed as a candidate therapy for depression, increased the levels of a protective protein, called sirtuin 1, in the hippocampus — a brain region involved in memory formation. The study with those findsings, “A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer’s disease mouse model,” was published in Scientific Reports. The
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