Dosing Starts in Phase 2 trial of Bryostatin-1 for Alzheimer’s

Dosing Starts in Phase 2 trial of Bryostatin-1 for Alzheimer’s
Neurotrope Bioscience announced that dosing of patients has started in its Phase 2 clinical trial to further evaluate Bryostatin-1, the company’s investigational candidate for the treatment of moderate to severe Alzheimer’s disease. "Completion of enrollment in our confirmatory Phase 2 trial is an important step toward understanding the transformative potential of Bryostatin in moderate to severe Alzheimer's disease, a neglected area of AD [Alzheimer's disease] research with no effective treatment options," Daniel Alkon, president and chief scientific officer of Neurotrope, said in a press release. The randomized, double-blind, and placebo-controlled Phase 2 study (NCT03560245) is comparing bryostatin to placebo for the treatment of moderately severe to severe Alzheimer's disease in individuals not receiving Namenda (memantine), an approved medicine marketed for  these disease stages. Patients who went through a wash-out period of 30 days without talking Namenda were allowed to enroll. A total of 108 individuals are being randomized to 20 micrograms (µg) Bryostatin-1 delivered into the blood (intravenously) or a placebo for 12 weeks, followed by a 30-day post-treatment evaluation. The first two doses were a loading dose 20% higher than the assigned dose and administered one week apart. In total, patients will receive seven doses of either Bryostatin-1 or placebo. The trial’s primary efficacy endpoint, or goal, is the s
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