ALZ-101 Vaccine Fares Well in Preclinical Study of Alzheimer’s Fish

ALZ-101 Vaccine Fares Well in Preclinical Study of Alzheimer’s Fish
Alzinova's ALZ-101 vaccine — designed to target toxic forms of the amyloid beta protein that drive neurodegeneration in Alzheimer’s disease — was well-tolerated in non-human primates and displayed efficacy in a fish model of the disease. A clinical study in patients with early Alzheimer’s disease now is expected to start later this year. Results of the study, “Oligomer-specific Active Vaccine Approach for the Treatment of Alzheimer's Disease," will be presented today by Anders Sandberg, PhD, chief scientific officer at Alzinova, during the 14th International Conference on Alzheimer's and Parkinson's Diseases and related disorders, running from March 26-31, Lisbon, Portugal. Alzheimer’s disease develops as a consequence of deposits of toxic clumps of mutant forms of amyloid beta protein in the brain. There are different forms of amyloid beta, however, the toxic form that promotes nerve cell death and neurodegeneration is its oligomer form — when several single units (monomers) of the protein aggregate. Recent preclinical studies suggests that within amyloid beta oligomers, only a small subset carries full neurotoxic potential. These findings challenge the concept that developing therapeutics specific for amyloid beta oligomers will provide an efficient approach. Researchers at Alzinova used AβCC peptide te
Subscribe or to access all post and page content.

Leave a Comment

Your email address will not be published. Required fields are marked *