#AANAM – Memantine as Add-on Therapy Seen to Ease Psychosis, Other Advanced Alzheimer’s Symptoms

#AANAM – Memantine as Add-on Therapy Seen to Ease Psychosis, Other Advanced Alzheimer’s Symptoms
Adding memantine to a cholinesterase inhibitor can significantly ease certain neuropsychiatric symptoms, including psychosis and troubling motor or nighttime behavior, in people with moderate-to-severe Alzheimer's disease, according to pooled data from three Phase 3 clinical trials. But it was not seen to be of any benefit in addressing problems of mood, like anxiety or depression, or frontal issues like disinhibition in this patient groups, researchers reported. This analysis was detailed at the American Academy of Neurology (AAN) 71st Annual Meeting, taking place through May 10 in Philadelphia, in the oral presentation, “The Effects of Memantine Added to Cholinesterase Inhibitors on NPI Behavioral Domains: Pooled Post Hoc Analysis of 3 Randomized Controlled Trials in Patients With Moderate to Severe AD.” Symptoms related to neuropsychiatric problems impact daily activities of people with advancing Alzheimer's, contributing to a poorer quality of life. These symptoms, which also include agitation or aggression, hallucinations, delusions, and irritability, can also be a considerable burden for patients and caregivers. Memantine, marketed in the U.S. as Namenda by Allergen, is an approved treatment for moderate-to-severe Alzheimer's disease. It works by blocking the ability of a brain signaling molecule called glutamate, produced in excess in Alzheimer's, from accessing and binding to NMDA r
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