Oral Anticoagulant Dabigatran Prevented Memory Loss in Mouse Model of Alzheimer’s, Study Shows

Oral Anticoagulant Dabigatran Prevented Memory Loss in Mouse Model of Alzheimer’s, Study Shows
Oral treatment over one year with an approved blood thinner called dabigatran prevented memory loss, preserved blood circulation in the brain and reduced the amount of senile plaques in a mouse model of Alzheimer’s disease. The study with that finding, “Long-Term Dabigatran Treatment Delays Alzheimer’s Disease Pathogenesis in the TgCRND8 Mouse Model,” was published in the Journal of the American College of Cardiology. Current Alzheimer's treatments provide only temporary relief from memory loss — a hallmark of the disease — and fail to halt disease progression or  reverse its symptoms. Previous studies have shown a link between vascular disease and Alzheimer's development. Reduced blood circulation leads to an insufficient supply of nutrients and oxygen to nerve cells, causing cell death. Researchers at Centro Nacional de Investigaciones Cardiovasculares (CNIC), in Spain, and at The Rockefeller University, in New York, evaluated whether dabigatran (sold under the brand name Pradaxa among others) could improve blood circulation and delay Alzheimer's progression. Dabigatran is an effective oral anti
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