INmune Bio’s XPro1595 May Help Lower Neuroinflammation Triggered by High Fat and Sugar Diet, Mouse Study Suggests

INmune Bio’s XPro1595 May Help Lower Neuroinflammation Triggered by High Fat and Sugar Diet, Mouse Study Suggests
Treatment with INmune Bio's lead candidate XPro1595 can help decrease neuroinflammation and amyloid beta accumulation triggered by a diet high in sugar and fats, according to results from a mouse model of Alzheimer’s disease (AD). Malú Tansey, PhD, professor of neuroscience and director of the Center for Translational Research in Neurodegenerative Disease at the University of Florida College of Medicine presented the results in a scientific poster titled  "Soluble TNF mediates obesogenic diet-induced alterations in peripheral and brain immunophenotype in a mouse model of Alzheimer’s disease,” at the Society for Neuroscience (SfN) 49thAnnual Meeting in Chicago, Illinois, Oct. 19–23. Our genetic makeup, along with our environmental exposures, are thought to be the main triggers for developing certain neurodegenerative conditions, including Alzheimer's. One of the main contributors in mediating the gene-environment effect in AD is the immune system. Neuroinflammation in the central nervous system (brain and spinal cord) is a key event underlying AD and it is mediated by an excessive activation of glial cells — nerve cells that surround and support neurons — and the overproduction of small pro-inflammatory molecules called cytokines. The levels of tumor necrosis factor (TNF), a pro-inflammatory cytokine, are often increased in AD patients. Importantly, TNF mediates conditions involved in metabolic syndrome. Environmental factors, such as a diet excessively high in fat and sugar, are known to trigger immune and metabolic responses that can result in metabolic syndrome and may increase the risk for AD. XPro1595 is an investigational anti-inflammatory therapy that blocks inflammation by selectively neutralizing soluble tumor necrosis factor (sT
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