Vaccine Combination Against Amyloid-Beta and Tau Proteins Shows Promise in Mouse Model of Alzheimer’s

Vaccine Combination Against Amyloid-Beta and Tau Proteins Shows Promise in Mouse Model of Alzheimer’s
Immunization with two experimental vaccines targeting the toxic forms of amyloid-beta and tau protein — two hallmarks of Alzheimer’s disease — triggered an immune response that reduced the levels of both proteins in the brain of a mouse model of the disease. The new combination vaccine, which could enter human trials within two years, could become a potential treatment to delay or slow down disease progression. The findings were published in an article, “Testing a MultiTEP-based combination vaccine to reduce Aβ and tau pathology in Tau22/5xFAD bigenic mice,” in the journal Alzheimer’s Research & Therapy. Current clinical trials have primarily tested therapies that target either amyloid-beta plaques or tau tangles, yet this approach has failed to delay disease progression. Neuroimaging studies support that the interaction between amyloid-beta and tau promote the neurodegeneration and cognitive decline that characterize Alzheimer’s. "Therefore, combinatorial therapies that concurrently target both [amyloid-beta] and tau might be needed for effective disease modification," the researchers wrote. In line with this hypothesis, scientists at the Institute for Molecular Medicine, University of California, Irvine, and Flinders University, in South Australia, targeted both amyloid-beta a
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