Scientists Use CRISPR-Cas9 as ‘DNA Scissors’ to Cut Out Alzheimer’s Gene in Mice, Study Shows

Scientists Use CRISPR-Cas9 as ‘DNA Scissors’ to Cut Out Alzheimer’s Gene in Mice, Study Shows
Using the gene editing technology CRISPR-Cas9 like a pair of "DNA scissors," researchers were able to essentially cut out the beta-secretase 1 (BACE1) gene in a mouse model of Alzheimer’s disease, a study shows. Deleting this gene — which drives the production of amyloid-β proteins in the brain that can accumulate on the outsides of neurons — resulted in better cognitive function and lower levels of amyloid-beta plaques, a key hallmark of the disease, the researchers said. The study, “In vivo neuronal gene editing via CRISPR–Cas9 amphiphilic nanocomplexes alleviates deficits in mouse models of Alzheimer’s disease,” was published in Nature Neuroscience. Genetics, or the DNA in cells that make up a person's genes, are known to be a key factor that contribute toward the development of Alzheimer’s. Several genes linked to the neurodegenerative disease have been identified. New technologies such
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