Alice Melão,  —

Articles by Alice Melão

Seizure-Like Brain Activity May Contribute to Alzheimer’s Development, Study Reports

Epileptic-seizure-like activity in a brain region called the hippocampus may contribute to the development of Alzheimer’s, according to a case study involving two patients. And an anti-epileptic medicine may be able to slow the disease’s progression, Massachusetts General Hospital researchers said. An additional finding was that seizure-like activity may be difficult to…

Corplex Donepezil Skin Patch Therapy Moves to Phase 1 Trial

A once-weekly transdermal patch delivers the most commonly prescribed treatment for Alzheimer’s disease in a way that is biologically equivalent to taking the medication orally, according to preliminary pilot study results. Corium International conducted the bioequivalence (BE) pilot study on its lead product, Corplex, which delivers donepezil — the same active…

Aquinnah Receives $10M in New Support to Develop Therapies for Alzheimer’s and ALS

Aquinnah Pharmaceuticals has received $10 million from two pharmaceutical companies, Pfizer and AbbVie, to advance its treatments for amyotrophic lateral sclerosis (ALS), Alzheimer’s disease, and other neurodegenerative diseases toward clinical trials. Together with a previous investment from Takeda Pharmaceuticals, Aquinnah’s research and development support totals $15 million. “We…

Concussions Can Lead to Earlier Onset of Alzheimer’s, Study Reports

Concussions can accelerate brain deterioration and cognitive decline in people genetically predisposed to Alzheimer’s, leading to earlier onset of the disease, according to a study. The findings could shed light on concussions’ impact on neurodegeneration and on Alzheimer’s incidence and development, researchers said. The study, “Mild traumatic brain injury…