News

EMA Committee Votes Against Approving Aduhelm in Europe

A European Medicines Agency (EMA) committee has voted against approving Biogen’s Aduhelm (aducanumab) as a treatment for Alzheimer’s disease. The EMA’s Committee for Medicinal Products for Human Use, known as CHMP, is expected to issue a formal ruling based on this so-called negative trend vote after its meeting in…

Lower Levels of Tau Marker Seen With Aduhelm in Phase 3 Trials

Treatment with Aduhelm (aducanumab) showed a significant correlation with lower blood levels of p-tau181, a disease biomarker, and lesser cognitive and functional decline in Alzheimer’s patients, according to a recent data analysis of two Phase 3 clinical trials. The data, analyzed from around 7,000 blood samples collected from more than…

AC Immune Extends Work Into TDP-43 Protein’s Role in Alzheimer’s

AC Immune has announced it will extend its partnership with researchers at the University of Pennsylvania to further study the mechanisms underlying disease-causing changes in  the transactive response DNA binding protein 43 kDa (TDP-43). Specifically, company researchers and those with the university’s Center for Neurodegenerative Disease Research at the Perelman School of Medicine…

Study Connects Herpes to Biological Risk for Alzheimer’s

A biological framework called the “microcompetition model” may explain why people infected with herpes simplex 1 (HSV1) are at increased risk of developing Alzheimer’s disease. “These dynamics explain the observed connection reported in many studies between the virus and Alzheimer’s disease, and provide a framework for further investigations,” researchers…

Mouse Study: 4 Approved Meds Are Potential Alzheimer’s Treatments

Detailed molecular signatures in three mouse models of Alzheimer’s disease at different disease stages allowed for identification of four approved medicines that may be potential Alzheimer’s treatments, a study revealed. The four medications that demonstrated efficiency are now used to treat hypertension (high blood pressure) and inflammation in humans.