News

Apolipoprotein E2 May Act as a Protective Shield in Alzheimer’s

In a new study entitled “Human ApoE Isoforms Differentially Modulate Glucose and Amyloid Metabolic Pathways in Female Brain: Evidence of the Mechanism of Neuroprotection by ApoE2 and Implications for Alzheimer’s Disease Prevention and Early Intervention” researchers reported a breakthrough discovery when they showed ApoE2 human protein is a…

Researchers Find Novel Drug Promising For Alzheimer’s Disease

New research presented during the 14th International Conference on Endothelin: Physiology, Pathophysiology and Therapeutics, focused on the effects of IRL-1620 in a rat model of Alzheimer’s disease (AD). The compound, which acts on the endothelin B (ETB) receptor, reduced learning and memory deficits and oxidative stress in the animals, showing potential as an AD…

Type 2 Diabetes May Contribute Towards Dementia Development

In a newly published paper in the Neurology journal entitled “Type 2 diabetes mellitus and biomarkers of neurodegeneration”, scientists from Australia found that neurodegenerative disease related dementia could be linked to type 2 diabetes. Neurodegenerative disorders occur as a consequence of a progressive loss of structure/function…

Study Sheds Light Into Alzheimer’s Disease Pathogenesis

Alzheimer’s Disease (AD) has been a topic of extensive research over the past three decades. The main focus of many studies has been the neurotoxicity associated with the accumulation of insoluble proteinaceous complexes in the brain. Closer examination has revealed these complexes to be plaques formed due to aggregation of…

Researchers Discover Key Role for Cholinergic Neurons

In a recent study entitled “Central Cholinergic Neurons Are Rapidly Recruited by Reinforcement Feedback” and published in Cell, Cold Spring Harbor Laboratory researchers found that cholinergic neurons play a key role in the response to unexpected triggers. Cholinergic neurons are nerve cells which mainly use the neurotransmitter acetylcholine…