News

Six months of treatment with bryostatin slowed cognitive decline in adults with moderately severe Alzheimer’s disease, according to new data from a Phase 2 clinical trial. These bryostatin-associated cognitive benefits over a placebo were maintained even four months after stopping treatment, the researchers noted — highlighting the long-term effects…

Treatment for two years with oral ALZ-801 (valiltramiprosate) sustained cognition and lowered levels of disease-related biomarkers in people with early Alzheimer’s disease carrying one or two copies of the disease-linked APOE4 genetic variant. These are the top-line findings of an ongoing Phase 2 clinical trial (NCT04693520), whose…

Anavex Life Sciences’ investigational oral therapy Anavex 2-73 (blarcamesine) significantly slows cognitive and functional decline in people with early Alzheimer’s disease, according to a new data analysis of a Phase 2b/3 clinical trial. The cognitive benefits were accompanied by a slower rate of brain shrinkage, a marker…

Among people with a genetic form of Alzheimer’s disease, those with more formal education tend to be older at disease onset, a new study suggests. Data indicate that the protective effects of education are particularly pronounced among patients with the highest genetic risk of Alzheimer’s, which suggests that “programs to…

As part of this month’s observance of World Alzheimer’s Month, supporters intend to raise awareness about Alzheimer’s disease and other types of dementia by pointing out the risk factors associated with the disorders. The Alzheimer’s Disease International (ADI) organizes the event, working with and supporting patient groups in…

Enrollment is complete and testing underway in a Phase 1b/2 clinical trial of Vaccinex’s experimental therapy pepinemab, which aims to slow disease progression in people with mild Alzheimer’s. One year of treatment for the 50 adults in the U.S. trial — called SIGNAL-AD (NCT04381468) and ongoing at…

Vaccine candidate UB-311 is safe, well tolerated, and triggered an antibody response against beta-amyloid in 93% of patients with mild Alzheimer’s disease, according to now published data from a Phase 2a trial. Immunization also led to nonsignificant trends in reducing beta-amyloid and slowing cognitive, functional, and dementia decline,…

The PrecivityAD blood test from C2N Diagnostics significantly influences clinicians’ decisions about whether to treat people with cognitive impairments for Alzheimer’s disease. C2N, which sponsored the recent study, believes those findings offer robust real-world evidence that blood biomarker testing in the clinic helps to guide treatment decisions…

Quest Diagnostics has launched a consumer-initiated blood test for adults in the U.S. that assesses Alzheimer’s disease risk by measuring levels of certain forms of the amyloid beta protein, a known marker of the neurodegenerative disorder. Called AD-Detect, the test is now the first of its kind…

Racial and ethnic minority groups in the U.S. are underrepresented in Alzheimer’s disease neuroimaging research, but the gap may be starting to close, according to a review study. Efforts to address the issue in recent years have been associated with small increases in minority inclusion, but much work remains…