Regulating Body Temperature May Ease Alzheimer’s Disease Symptoms
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Researchers at Université Laval in Canada demonstrated that aging mice in a model of Alzheimer’s disease (AD) were less able to regulate their body temperatures, and when exposed to a cold environment showed increased AD manifestations. These results suggest correction of thermoregulation might be a therapeutic avenue for Alzheimer’s.
The study, “Impaired thermoregulation and beneficial effects of thermoneutrality in the 3xTg-AD model of Alzheimer’s disease (AD),” was published in Neurobiology of Aging.
The accentuated incidence of AD in older people is accompanied by a reduction in energy metabolism and core body temperature. Researchers investigated if changes in body temperature regulation would amplify the debilitating manifestations of the disease, and if such effects would manifest in a vicious circle, as areas of the brain involved in thermoregulation are affected in Alzheimer’s.
To test the hypothesis, the team used a mouse model of AD, the 3xTg-AD, that presents the hallmarks of the disease, including beta-amyloid production, formation of plaque, synapse loss, and memory loss starting at 6 months. Compared to normal mice, the AD mice were less effective in maintaining their body temperature, spontaneously developing a lower basal temperature as they grew older. The difference between transgenic and normal control mice reached almost 1° Celsius (about 1.8° Fahrenheit) at 12 months of age. Moreover, AD mice were more vulnerable to low temperatures, and clinical manifestations of AD more noticeable when they were exposed to a colder environment. After a 24-hour exposure to cold (4°C/39°F), key pathological markers of AD were worse, namely abnormal tau protein and loss of synaptic proteins. Raising the body temperature in the transgenic animals improved memory, and mitigated amyloid and synapse pathologies within a week.
Researchers believe that such findings hint at a possible new therapeutic avenue, warranting investigation in people. “Our findings suggest that it is worth exploring the treatment of thermoregulation among seniors suffering from Alzheimer’s,” Professor Frédéric Calon, the study’s lead author, said in a news release. “If our conclusions are confirmed, it would be a relatively easy therapeutic option to implement because body temperature can be increased through physical activity, diet, drugs, or simply by increasing the ambient temperature.”
Dan Bartoes
Our own empirical evidence would agree. My wife is more 'susceptible' to cold, but more importantly, has wicked hot flashes (much more than when she was post-menopausal) which seem to precede an alzheimer's moment/event. A body temperature regulating drug would help immensely!
Dariush
In the Name of God, the Compassionate, the Merciful.
Hello
We have solved the fatal puzzle of Alzheimer's disease (AD). Although we would like to announce the way to defeat AD. We want experts' professional opinion and consult with them, but ....
Although the causes of Alzheimer's include a combination of genetic, lifestyle, and environmental factors.
But we can prove:
1. In increasing the risk of development Alzheimer's, hypothermia and Herpesviridae family are more important than other environmental factors.
In fact hypothermia provides the conditions for the activity of Herpesviridae.
2. We know which lifestyle makes the body ready to accept these viruses? (We know which lifestyle makes my body temperature drops?)
3. We can show this fact that Alzheimer’s disease is not just a disease of the brain but of the body as well.
The keys to solve this puzzle are in our hands, Unique keys that will arouse the astonishment of the experts and will lead to definitive cure and prevention of this disease.
As soon as the world not only forget Alzheimer's but also will know how develop a super memory and will know elixir of youth.
"No time to lose"
'Remember Me'
Taheri Dariush