Antibody Targeting Protein of Blood May Work Against Neurodegeneration, Study Reports

Antibody Targeting Protein of Blood May Work Against Neurodegeneration, Study Reports
A newly developed antibody targeting a protein called fibrin was seen to prevent inflammation and oxidative stress induced by amyloid aggregates in the brains of a mouse model of Alzheimer’s disease. These findings may pave the way for a new way of treating and preventing the neurodegeneration associated with Alzheimer’s and other neurological diseases. The study, “Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration,” was published in the journal Nature Immunology. Abnormal activation of immune cells in the brain is known to contribute to the oxidative stress and cognitive decline linked to Alzheimer’s disease. Although little is still known about the signals that trigger immune cells, research suggests that disruption of the protective blood-brain barrier, and the consequent deposition of fibrin, are linked to the development of neurological diseases. The blood-brain barrier consists of specialized cells that form a semi-permeable barrier that separates the brain from the circulatory system. Damage can allow fibrinogen, a soluble protein that's also important to clotting of the blood, to leak into the central nervous system that includes the brain, where it is transformed into the insoluble protein fibrin. Fibrinogen has been proposed as a biomar
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