NHE6 Inhibition Could Help Prevent Late-onset Alzheimer’s, Researchers Say

NHE6 Inhibition Could Help Prevent Late-onset Alzheimer’s, Researchers Say
Inhibiting a protein called NHE6 is a potential strategy to prevent the damaging effect of ApoE4 and the associated risk of late-onset Alzheimer’s disease, a study suggests. The study, “Reversal of ApoE4-induced recycling block as a novel prevention approach for Alzheimer’s disease,” was led by University of Texas Southwestern researchers and published in the journal eLife. The ApoE protein is involved in the transport and metabolism of fatty molecules such as cholesterol. It is present in the human body in three major variants known as ApoE2, ApoE3, and ApoE4. The ApoE4 variant is the second most common in the general population. However, evidence has demonstrated that ApoE4 protein is found more frequently in patients with dementia, being present in more than half of patients with Alzheimer’s disease. Reports have suggested that the ApoE protein is involved in beta-amyloid protein clearance and burden, which is impaired in Alzheimer’s patients. It is thought that APOE gene variants can directly affect brain tissue, blood-brain barrier, and blood vessels, resulting in alte
Subscribe or to access all post and page content.