Salt, Acidic Conditions Promote Alzheimer’s Hallmark Amyloidosis, Study Shows

Salt, Acidic Conditions Promote Alzheimer’s Hallmark Amyloidosis, Study Shows
Salt together with acidic conditions can change the 3D structure of the beta2-microglobulin protein and promote the formation of amyloid fibrils — a hallmark of Alzheimer’s disease. The study, “Conformational properties relevant to the amyloidogenicity of beta2-migroglobulin analyzed using pressure and salt dependent chemical shift data” was published in the Journal of Physical Chemistry. Amyloidosis is a condition characterized by the accumulation of inappropriately folded amyloid fibrils — long, abnormal protein fibrils — in tissues or organs, disrupting their normal function. The condition is also
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