Patricia Inacio, PhD,  science writer—

Neuroinflammation in the central nervous system is a known key event in Alzheimer’s pathogenesis and has long been proposed as a therapeutic target, but studies conducted in the early 2000s of potential anti-inflammatory treatments didn’t produce the hoped for outcomes. Now a renewed interest is emerging in Alzheimer’s disease (AD) treatments targeting neuroinflammation, still a…

In a new study entitled “Rescue of long-range circuit dysfunction in Alzheimer’s disease models,” researchers discovered why Alzheimer’s disease patients experience sleep disturbances and discovered potential therapeutics to counteract this effect. The team observed that improving sleep in mouse models of Alzheimer’s disease also benefits their memory performance. The…

In a new study entitled “Histone Deacetylase Inhibition via RGFP966 Releases the Brakes on Sensory Cortical Plasticity and the Specificity of Memory Formation” a team of researchers at Rutgers University discovered that the drug RGFP966 changes how audible memory is formed and that RGFP966-treated rats have stronger memories that…

In a new study entitled “Human umbilical cord blood-derived monocytes improve cognitive deficits and reduce ß-amyloid pathology in PSAPP mice” an international team of scientists showed that infusion of human umbilical cord blood cells (HUCBCs) into a mice model of Alzheimer’s disease improves animals’ cognitive performance by clearing amyloid-beta (Aβ)…

In a new study entitled “Human ApoE Isoforms Differentially Modulate Glucose and Amyloid Metabolic Pathways in Female Brain: Evidence of the Mechanism of Neuroprotection by ApoE2 and Implications for Alzheimer’s Disease Prevention and Early Intervention” researchers reported a breakthrough discovery when they showed ApoE2 human protein is a…

In a new study entitled “Genetic Analysis of Association Between Calcium Signaling and Hippocampal Activation, Memory Performance in the Young and Old, and Risk for Sporadic Alzheimer Disease” a team of researchers discovered a common group of genes that control human memory performance in healthy young and old…

In a new study entitled “BDNF Reduces Toxic Extrasynaptic NMDA Receptor Signaling via Synaptic NMDA Receptors and Nuclear Calcium-induced Transcription of inhba/Activin A” a team of scientists at Heidelberg University discovered a mechanism that protects neurons from death after brain damage, such as a stroke. The…

Monoclonal antibodies developed by a team of scientists at the NYU Langone Medical Center’s Center for Cognitive Neurology may be a stepping-stone towards potential new treatments against neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease. The majority of neurodegenerative diseases, such as Alzheimer’s, Lewy Body and other dementias, Parkinson’s and prion diseases…

In a new study entitled “Novel DNA repair mechanism brings new horizons: Researchers discover new mechanism of DNA repair, which will help to treat and to prevent diseases in the future” researchers discovered a new mechanism on how the DNA molecule repairs itself which may translate into…

In a new study entitled “Aβ(1–42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer’s disease,” researchers established the molecular structure of a key form of amyloid-β (Aβ) protein, Aβ42. This finding allows researchers to understand how Aβ42 accumulates in plaque aggregates in the brain of…