All failed attempts to produce a viable vaccine against amyloid-beta in Alzheimer’s disease have one thing in common — they all used vaccine adjuvants that elicit the wrong kind of immune response, says Qantu Therapeutics’ president and CSO, Dante J. Marciani, in a sweeping retrospective analysis that covers errors in past and…
Results of a new study published in the Journal of Alzheimer’s Disease by a team of researchers at the University of Toronto, Wilfrid Laurier University in Waterloo, Ontario, and the Baycrest Centre in Toronto, Canada, reports the investigators’ assessment of the effect of stimulating…
Patients with Alzheimer’s disease (AD) are more likely to develop diabetes due to an impairment in insulin signaling in the brain, according to a new study titled “Increased susceptibility to metabolic dysregulation in a mouse model of Alzheimer’s disease is associated with impaired hypothalamic insulin signaling and elevated…
Georgetown University researchers reported what is thought to be the first confirmed case of Alzheimer’s disease in a HIV-positive patient, a 71-year-old man with amyloid deposits in the brain detected by a scan. The case report highlights the importance of further study into HIV-related neurological decline, and raises the possibilty that Alzheimer’s…
Researchers at two Norwegian institutions found that deficits in the mitochondrial protein PITRM1 led to an accumulation of amyloid-beta, whose deposits in the brain are known to cause Alzheimer’s disease. The findings, drawn from a study of a family with a rare genetic defect, further suggest that mitochondria is a key player in neurodegenerative diseases.
A family of six mitochondrial small humanin-like peptides (SHLPs) showed promising effects on cell survival and metabolism in preclinical studies of aging, a finding with long-reaching implications for age-related conditions such as Alzheimer’s disease. The findings were announced by the biotechnology company CohBar, which holds the exclusive license for developing SHLPs…
New guidelines for Alzheimer’s disease patient care and caregiver support developed by the Alzheimer’s Association’s National Plan Care and Support Milestone Workgroup are detailed in a paper, “Report on milestones for care and support under the U.S. National Plan to Address Alzheimer’s Disease,” published…
A review analysis by Professor Melissa Schilling, a strategy and innovation expert at the New York University’s Stern School of Business, suggests a strong link between diabetes and Alzheimer’s disease. The study, “Unraveling Alzheimer’s: Making Sense of the Relationship between Diabetes and Alzheimer’s Disease,” was published in…
Face recognition difficulties in Alzheimer’s patients have typically been attributed to underlying episodic and semantic memory impairment. Dr. Sven Joubert, Ph.D., from the Centre de recherche de l’Institut universitaire de gériatrie de Montréal, and colleagues have found that more than causing memory problems, Alzheimer’s also impairs visual face perception, a…
Researchers at Université Laval in Canada demonstrated that aging mice in a model of Alzheimer’s disease (AD) were less able to regulate their body temperatures, and when exposed to a cold environment showed increased AD manifestations. These results suggest correction of thermoregulation might be a therapeutic avenue for Alzheimer’s. The study, “Impaired thermoregulation and…
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