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A research team attempting to identify new biomarkers of Alzheimer’s disease has found that young subjects at high genetic risk of Alzheimer’s development — while moving through a virtual maze — showed lower brain cell activity involved in spatial navigation than a control group, revealing differences in the brain decades before possible disease onset. The…

A study published in Cell Stem Cell journal entitled “Small Molecules Efficiently Reprogram Human Astroglial Cells into Functional Neurons” showed that treatment of astroglial cells with a cocktail of nine small molecules resulted in neuron-like cells with similar electrical and neurotransmitter activities as functional…

Researchers at the Thomas Jefferson University have found a new protein involved in synaptic pathways with important implications in Alzheimer’s disease. The research paper, entitled “Anchoring and synaptic stability of PSD-95 is driven by ephrin-B3,” was published in Nature Neuroscience. Synapses are electrical or chemical signals between…

A study published in Stem Cell Reports, entitled “Neural Stem Cells Rescue Cognitive and Motor Dysfunction in a Transgenic Model of Dementia with Lewy Bodies through a BDNF-Dependent Mechanism,” reports that neural stem cell (NSC) transplantation into mice suffering from dementia with Lewy bodies (DLB) significantly improved…

Researchers from the Rowan University School of Osteopathic Medicine have reported the ongoing development of a blood test for early Alzheimer’s’ disease diagnostic. The preliminary data was presented during the recent Osteopathic Medical Conference & Exposition (OMED 15) in Orlando, Florida. The innovative blood test relies on the detection of autoantibodies as blood biomarkers of…

A new study reports the finding of fungal cells and hyphae in tissue from different regions of the central nervous system (CNS) in Alzheimer’s disease (AD) patients. The research article, entitled “Different Brain Regions are Infected with Fungi in Alzheimer’s Disease”, was published in Scientific Reports. AD…

Findings from a recent study published in the British Journal of Psychiatry revealed that antipsychotic drugs are used by Alzheimer’s disease (AD) patients more frequently than in the general population — already 2-3 years before an Alzheimer’s diagnosis. The team of researchers from the University of Eastern Finland also…

In a study recently published in the journal Brain a team of researchers found an immune system gene associated with higher rates of amyloid plaque buildup in the brains of patients with Alzheimer’s Disease and older adults at risk for the condition. The mechanisms underlying amyloid…

Clinical-stage biopharmaceutical company Anavex Life Sciences Corp. is working on an investigational oral treatment for Alzheimer’s disease called ANAVEX 2-73, with full PART A data and preliminary PART B data from its ongoing Phase 2a clinical trial to be presented during the Clinical Trials on Alzheimer’s Disease (CTAD) conference, November 5 and…

In a new study entitled “Histone Deacetylase Inhibition via RGFP966 Releases the Brakes on Sensory Cortical Plasticity and the Specificity of Memory Formation” a team of researchers at Rutgers University discovered that the drug RGFP966 changes how audible memory is formed and that RGFP966-treated rats have stronger memories that…