The pharmaceutical company Cortexyme announced that the first group of participants has been dosed in the Phase 1 clinical trial of its lead compound, COR388, for the treatment of Alzheimer’s disease. Because no new successful developments have emerged in Alzheimer’s therapeutics in the last 15 years, researchers have been trying…
Eisai and Biogen had hoped that using an advanced statistical method to analyze Phase 2 clinical trial results would show at 12 months rather than the normal 18 that their Alzheimer’s therapy BAN2401 was effective. But an independent trial review body declared the 12-month results inconclusive, so the Japanese and…
With 2017 behind us, Alzheimer’s News Today looks forward to bringing our readers news and updates on Alzheimer’s disease research discoveries, treatment developments, clinical trials, and events in the year ahead. But as a reminder of all the great work being done to find treatments and improve the lives…
Pain Therapeutics’ Alzheimer’s therapy PTI-125 was safe, and patients tolerated it well, a Phase 1 clinical trial shows. The therapy is aimed at countering a faulty version of the filamin A protein. Scientists believe this abnormal version contributes to Alzheimer’s by facilitating the buildup of toxic nerve cell plaque and promoting…
BAN2401, an investigational anti-amyloid beta antibody therapy for Alzheimer’s disease, has failed to reach the primary endpoint of a Phase 2 clinical trial measured after 12 months of therapy. Study 201 will continue following the predefined protocol, where a comprehensive analysis will be performed after an 18-month treatment period. Final results…
Four ways of possibly preventing dementia late in life — prescription medicines, over-the-counter (OTC) supplements and vitamins, physical activity, and cognitive training — are all seem to be inadequate at that task, a Minnesota Evidence-based Practice Center (EPC) study showed. Researchers conducted a systematic review of published to determine if…
Giving mice with Alzheimer’s a canola oil-rich diet for six months led to their memory and learning ability worsening, a study reports. The research, “Effect of canola oil consumption on memory, synapse and neuropathology in the triple transgenic mouse model of Alzheimer’s disease,” was published in the journal Scientific Reports.
Three leading Alzheimer’s researchers are forming a consortium to improve clinical trials in the field — an effort boosted by a $70 million grant from the National Institutes of Health. Goals of the Alzheimer’s Clinical Trials Consortium include sharing information and resources to make drug development more efficient and finding better…
Certain variations found in genes that correlate with intelligence and may affect “cognitive reserve” are evident in people with higher levels of education and appear to work to protect against Alzheimer’s disease (AD), new research shows. Better educating young adults may help to reduce the expected rise in AD incidence as…
Aricept (donepezil hydrochloride) is now approved in China to treat patients with severe Alzheimer’s disease, as well as those with mild or moderate disease, Eisai recently announced. The extended approval was based on the results of a Phase 3 clinical trial (NCT01404169) conducted in that country. The study was…
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