News

Pain Therapeutics’ Alzheimer’s therapy PTI-125 was safe, and patients tolerated it well, a Phase 1 clinical trial shows. The therapy is aimed at countering a faulty version of the filamin A protein. Scientists believe this abnormal version contributes to Alzheimer’s by facilitating the buildup of toxic nerve cell plaque and promoting…

BAN2401, an investigational anti-amyloid beta antibody therapy for Alzheimer’s disease, has failed to reach the primary endpoint of a Phase 2 clinical trial measured after 12 months of therapy. Study 201 will continue following the predefined protocol, where a comprehensive analysis will be performed after an 18-month treatment period. Final results…

Four ways of possibly preventing dementia late in life — prescription medicines, over-the-counter (OTC) supplements and vitamins, physical activity, and cognitive training — are all seem to be inadequate at that task, a Minnesota Evidence-based Practice Center (EPC) study showed. Researchers conducted a systematic review of published to determine if…

Giving mice with Alzheimer’s a canola oil-rich diet for six months led to their memory and learning ability worsening, a study reports. The research, “Effect of canola oil consumption on memory, synapse and neuropathology in the triple transgenic mouse model of Alzheimer’s disease,” was published in the journal Scientific Reports.

Three leading Alzheimer’s researchers are forming a consortium to improve clinical trials in the field — an effort boosted by a $70 million grant from the National Institutes of Health. Goals of the Alzheimer’s Clinical Trials Consortium include sharing information and resources to make drug development more efficient and finding better…

Certain variations found in genes that correlate with intelligence and may affect “cognitive reserve” are evident in people with higher levels of education and appear to work to protect against Alzheimer’s disease (AD), new research shows. Better educating young adults may help to reduce the expected rise in AD incidence as…

Aricept (donepezil hydrochloride) is now approved in China to treat patients with severe Alzheimer’s disease, as well as those with mild or moderate disease, Eisai recently announced. The extended approval was based on the results of a Phase 3 clinical trial (NCT01404169) conducted in that country. The study was…

Marriage appears to be a strong and favorable factor in a person’s risk of developing dementia, with evidence suggesting that married people are at considerably lower risk than people who never marry or those who have lost a partner. The study, “Marriage and risk of dementia: systematic review…

Canadian researchers have developed a simple tool to track cognitive performance, so doctors can identify those at higher risk of developing Alzheimer’s or other forms of dementia. QuoCo consists of charts that show what a healthy person’s cognitive performance ought to be. It takes into account the person’s age,…

Probiodrug and Crossbeta Biosciences are extending a partnership that Probiodrug believes will help it continue developing a potential Alzheimer’s therapy. Under the partnership, established in 2016, the companies are using a proprietary Crossbeta technology to try to create biomarkers specific to Alzheimer’s as opposed to   neurodegenerative diseases in general.