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Memory, Cognition in Mice with Alzheimer’s Improve When Inflammatory Cells Reduced, Researchers Say

Researchers have successfully reduced the levels of inflammatory cells in the central nervous system linked to inflammation using pharmacological drugs. This decrease translated into improved memory, cognition, and neuronal survival in mouse models of Alzheimer’s disease. The research paper, “Eliminating microglia in Alzheimer’s mice prevents neuronal loss without modulating amyloid-β pathology,” was…

In Mouse Model of Alzheimer’s Disease, Specific Nanoparticles Successfully Suppressed Neuronal Death

Scientists from the Center for Nanoparticle Research at South Korea’s Institute for Basic Science (IBS), in collaboration with researchers at Seoul National University, have developed mitochondria-targeting ceria nanoparticles, a potential therapeutic candidate for mitochondrial oxidative stress and seen as one of the possible pathogenic pathways involved in the onset of Alzheimer’s…

In Alzheimer’s Disease, Adaptive Immune System Plays Important Role

Researchers have discovered that a genetic elimination of peripheral immune cell populations leads to a more rapid development of amyloid brain plaques (which are present in Alzheimer’s patients), worsening of neuroinflammation, and dysfunction of microglial activity. The study, “The adaptive immune system restrains Alzheimer’s disease pathogenesis by modulating microglial function,”…

Global Alzheimer’s Disease Phase 3 Clinical Trial Completes Enrollment

Takeda Pharmaceutical Company and partner Zinfandel Pharmaceuticals announced the completion of patient enrollment in the TOMMORROW Phase 3 Clinical Trial, one of the largest studies ever to be executed in mild cognitive impairment and Alzheimer’s disease (AD). Previous research has shown that individuals who develop mild cognitive impairment (MCI) are…

Researchers Seek Families Especially Susceptible to Alzheimer’s Disease for Biomarkers, Genetic Mutations

Researchers at Atlanta’s Emory University, under the guidance of neurologist Dr. Allan Levey, are studying the lineage of a specific family whose members are exceptionally prone to the development of late-onset Alzheimer’s disease in the search for new causes, such as novel genetic mutations, biomarkers, and brain changes. The ongoing…

Researchers of Alzheimer’s, Other Neurological Diseases Say ‘Mini-Brains’ May Be Effective in Testing New Drugs

Researchers at the Johns Hopkins Bloomberg School of Public Health have developed “mini-brains” that may present a more accurate and effective way of testing new drugs for many neurological disorders, such as Alzheimer’s disease. These human cell-derived structures, which represent an existing new alternative to animal testing, were recently discussed in a…