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In a new study entitled “Human ApoE Isoforms Differentially Modulate Glucose and Amyloid Metabolic Pathways in Female Brain: Evidence of the Mechanism of Neuroprotection by ApoE2 and Implications for Alzheimer’s Disease Prevention and Early Intervention” researchers reported a breakthrough discovery when they showed ApoE2 human protein is a…

New research presented during the 14th International Conference on Endothelin: Physiology, Pathophysiology and Therapeutics, focused on the effects of IRL-1620 in a rat model of Alzheimer’s disease (AD). The compound, which acts on the endothelin B (ETB) receptor, reduced learning and memory deficits and oxidative stress in the animals, showing potential as an AD…

A gene signature that could be used to predict the onset of diseases, such as Alzheimer’s, years in advance has been developed in a study published in the open access journal Genome Biology. The objective of the study, entitled “A novel multi-tissue RNA diagnostic of…

In a newly published paper in the Neurology journal entitled “Type 2 diabetes mellitus and biomarkers of neurodegeneration”, scientists from Australia found that neurodegenerative disease related dementia could be linked to type 2 diabetes. Neurodegenerative disorders occur as a consequence of a progressive loss of structure/function…

In a new study entitled “Genetic Analysis of Association Between Calcium Signaling and Hippocampal Activation, Memory Performance in the Young and Old, and Risk for Sporadic Alzheimer Disease” a team of researchers discovered a common group of genes that control human memory performance in healthy young and old…

Alzheimer’s Disease (AD) has been a topic of extensive research over the past three decades. The main focus of many studies has been the neurotoxicity associated with the accumulation of insoluble proteinaceous complexes in the brain. Closer examination has revealed these complexes to be plaques formed due to aggregation of…

In a new study entitled “BDNF Reduces Toxic Extrasynaptic NMDA Receptor Signaling via Synaptic NMDA Receptors and Nuclear Calcium-induced Transcription of inhba/Activin A” a team of scientists at Heidelberg University discovered a mechanism that protects neurons from death after brain damage, such as a stroke. The…

In a recent study entitled “Aberrant Lipid Metabolism in the Forebrain Niche Suppresses Adult Neural Stem Cell Proliferation in an Animal Model of Alzheimer’s Disease”, published in the journal Cell Stem Cell, a team of Canadian researchers led by Dr. Karl J. L. Fernandes found that fat droplets…

In a recent study entitled “Central Cholinergic Neurons Are Rapidly Recruited by Reinforcement Feedback” and published in Cell, Cold Spring Harbor Laboratory researchers found that cholinergic neurons play a key role in the response to unexpected triggers. Cholinergic neurons are nerve cells which mainly use the neurotransmitter acetylcholine…

Results from a recent study published in the Journal of the American Medical Association, showed that omega-3 supplements did not slow cognitive decline in 4,000 older patients that were followed over a five-year period. These results are divergent with some evidence indicating that a diet high in…