Alzheimer’s Disease (AD) has been a topic of extensive research over the past three decades. The main focus of many studies has been the neurotoxicity associated with the accumulation of insoluble proteinaceous complexes in the brain. Closer examination has revealed these complexes to be plaques formed due to aggregation of…
In a new study entitled “BDNF Reduces Toxic Extrasynaptic NMDA Receptor Signaling via Synaptic NMDA Receptors and Nuclear Calcium-induced Transcription of inhba/Activin A” a team of scientists at Heidelberg University discovered a mechanism that protects neurons from death after brain damage, such as a stroke. The…
In a recent study entitled “Aberrant Lipid Metabolism in the Forebrain Niche Suppresses Adult Neural Stem Cell Proliferation in an Animal Model of Alzheimer’s Disease”, published in the journal Cell Stem Cell, a team of Canadian researchers led by Dr. Karl J. L. Fernandes found that fat droplets…
In a recent study entitled “Central Cholinergic Neurons Are Rapidly Recruited by Reinforcement Feedback” and published in Cell, Cold Spring Harbor Laboratory researchers found that cholinergic neurons play a key role in the response to unexpected triggers. Cholinergic neurons are nerve cells which mainly use the neurotransmitter acetylcholine…
Results from a recent study published in the Journal of the American Medical Association, showed that omega-3 supplements did not slow cognitive decline in 4,000 older patients that were followed over a five-year period. These results are divergent with some evidence indicating that a diet high in…
Scientist have found evidences of where the brain records the place and time of real-life memories. In a study published in Proceedings of the National Academy of Science, Ohio State University researchers showed that the brain patterns related to the activation of this specific region when memories were recalled were a clear…
Results from a recent study published in the Journal of Neurology Neurosurgery & Psychiatry revealed nine possibly modifiable risk factors that may contribute towards up to two thirds of all cases of Alzheimer’s disease (AD) worldwide. However, the results also suggest that AD is a complex condition with many risk…
A study published in the journal Nature Neuroscience revealed new insights into the role played by astrocytes in neurological disorders such as Alzheimer’s disease. The study was conducted by an international research team and is entitled “Nuclear pore complex remodeling by p75NTR cleavage controls…
Dementia can be defined as a disease which affects the brain’s ability to go through a clear process of thinking, reasoning and remembering. The disease can affect several parts of the brain and patients with dementia may face difficulties dealing with language, memory loss, impaired visual-spatial orientation, loss of problem…
This week, Ohio State University (OSU) researcher, Dr. Rene Anand, PhD, MS whose laboratory is focused on studying how genes and the environment interact to increase susceptibility to neurodevelopmental, neuropsychiatric and neurodegenerative disorders in an effort to develop brain organoids (three-dimensional organ-bud grown in a laboratory) to study…
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