Biogen is acquiring from Pfizer investigational therapy PF-05251749, a small molecule being developed to treat sundowning in Alzheimer’s disease and irregular sleep wake rhythm disorder (ISWRD) in Parkinson’s disease. The company plans to begin a Phase 1b clinical trial by the end of this year,…
Caroline Snoeij remembers a 94-year-old man with dementia weighing whether to make healthcare-related visits to her farm in central Holland. “I’ll come if you’ll let me clean the outside of the eggs” your chickens lay, he said in his best bargaining tone. A bemused Caroline and her husband IJsbrand agreed. The…
Individuals, especially east Asians who carry a mutation in a key enzyme involved in alcohol metabolism, have an increased risk of developing Alzheimer’s disease as a consequence of regular alcohol consumption, according to recent research. The study, “Aldehyde dehydrogenase 2 activity and aldehydic load contribute to neuroinflammation and Alzheimer’s…
When it comes to nutrition support for Alzheimer’s disease, we often focus on nutrient- and energy-specific recommendations to support cognitive brain function and the gut microbiome, as well as to reduce inflammation. A lesser-known consideration however, is…
Immunization with two experimental vaccines targeting the toxic forms of amyloid-beta and tau protein — two hallmarks of Alzheimer’s disease — triggered an immune response that reduced the levels of both proteins in the brain of a mouse model of the disease. The new combination…
Researchers have discovered a likely reason why the most common form of the CD33 protein is a risk factor for Alzheimer’s disease, a finding that could open new therapeutic avenues targeting the protein, a study reports.
The Bacillus Calmette-Guérin (BCG) vaccine, which provides protection against tuberculosis, can reduce the incidence of Alzheimer’s disease in patients with bladder cancer — and potentially provide new avenues to explore this effect in the general population, according to a recent study. The study, “Bacillus Calmette-Guérin…
The Alzheimer’s Association (AA) has launched an initiative to help U.S. health systems and clinicians enhance dementia care, and do so more cost-effectively. The non-profit organization is seeking to partner with some 300 health systems nationally to offer solutions for improving health outcomes among patients with Alzheimer’s…
Ionis Pharmaceuticals has licensed IONIS-MAPTRx (BIIB080), its investigational antisense therapy for the treatment of Alzheimer’s disease, to Biogen. IONIS-MAPTRx is an antisense therapy — an approach to fighting diseases using short DNA-like molecules called antisense oligonucleotides — that has been designed to reduce the production…
Throughout 2019, Alzheimer’s News Today delivered daily coverage of emerging research, key findings, treatment developments, and clinical trials related to Alzheimer’s disease. We look forward to bringing the same quality of coverage to those living with Alzheimer’s in the coming year. Here are the 10 most-read stories of 2019,…
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