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Neuroinflammation in the central nervous system is a known key event in Alzheimer’s pathogenesis and has long been proposed as a therapeutic target, but studies conducted in the early 2000s of potential anti-inflammatory treatments didn’t produce the hoped for outcomes. Now a renewed interest is emerging in Alzheimer’s disease (AD) treatments targeting neuroinflammation, still a…

Sometimes more is not necessarily better. This may especially be true of Alzheimer’s disease clinical studies, too many of which have been tried and failed, leading top scientists to question their design and execution. Better planning in the application of more promising approaches might make more sense — and improve a…

Results from a recent study presented at the 8th International Conference on Clinical Trials for Alzheimer’s Disease (CTAD) revealed that aerobic exercise improves brain function and reduces neurodegeneration markers in older adults at risk for Alzheimer’s disease (AD). Study results also indicate that aerobic exercise may be a potential disease-modifying intervention…

During the  8th International Conference on Clinical Trials for Alzheimer’s Disease (CTAD) held in Barcelona, Spain, data from the MAPT study of older adults with memory lapses was presented. This study suggested that the combination of a multi-domain nutritional and stimulation intervention plus an omega-3 fatty acid supplementation slows…

In a recent study published in the journal JAMDA, a team of researchers from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King’s College London determined that online games that challenge memory and cognitive skills could beneficially improve daily life for older people. The team demonstrated specifically…

Findings from a recent study published in the Journal of Alzheimer’s Disease revealed that chemical alterations in brain cells triggered by disruptions in the body’s day-night cycle may be an underlying cause of the memory and learning loss observed in Alzheimer’s disease (AD). The study, conducted by University of California researchers,…

U.K. researchers, headed by the Institute of Psychiatry, King’s College London, have found that donepezil administered during the later stages of Alzheimer’s might temporarily decrease the likelihood that someone will need to move into a nursing home. The study report, entitled “Nursing home placement in the Donepezil and…

Scientists at Massachusetts General Hospital (MGH) have published a new study describing how neurofibrillary tangles — one of the hallmarks of Alzheimer’s disease — develop. Alzheimer’s disease is characterized by a progressive degeneration of specific brain regions, starting with those areas involved in memory. Two proteins are found at…

In a new study entitled “Rescue of long-range circuit dysfunction in Alzheimer’s disease models,” researchers discovered why Alzheimer’s disease patients experience sleep disturbances and discovered potential therapeutics to counteract this effect. The team observed that improving sleep in mouse models of Alzheimer’s disease also benefits their memory performance. The…

Researchers from NYU Langone Medical Center developed a novel strategy to extract large quantities of brain protein from formalin-fixed, paraffin-embedded (FFPE) tissues in patients with Alzheimer’s, an advancement that may lead to a new understanding of brain protein changes found in the disease. The study entitled “Proteomic…