Researchers discovered a potential cause for the disrupted sleep patterns observed in Alzheimer’s disease patients. The study, “Melanopsin retinal ganglion cell loss in Alzheimer’s disease,” associates the degradation of a subset of eye cells involved in circadian rhythm regulation with the sleep dysfunction observed in AD, and was published in…
Men undergoing androgen deprivation therapy (ADT) for prostate cancer could be almost twice as likely to be diagnosed with Alzheimer’s disease (AD) than those not treated with ADT. The findings, in a study published in the Journal of Clinical Oncology, also show that the risks of developing Alzheimer’s might continue…
A recent study suggests that amyloid beta plaques may alter normal blood flow to brain tissue and contribute to development of Alzheimer’s disease. The paper, published in the journal Brain, is entitled “Vascular amyloidosis impairs the gliovascular unit in a mouse model of Alzheimer’s disease.”…
Yale School of Public Health researchers have demonstrated that stress caused by negative attitudes and beliefs toward aging can lead to pathological brain damage associated with Alzheimer’s disease. The research paper, the first to correlate a cultural and psychosocial risk factor to Alzheimer’s disease onset, was published online in the…
Alzheimer’s disease and cognitive deficits could be linked to reduced neuronal levels of BRCA1, a protein typically targeted in cancer research. These were the results of a study entitled “DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice,” published in Nature Communications.
Researchers have discovered a network of nine genes that play a key role in Alzheimer’s disease onset. The study entitled “APOE*E2 allele delays age of onset in PSEN1 E280A Alzheimer’s disease” was published in the journal Molecular Psychiatry. Alzheimer’s disease age of onset varies greatly between individuals, a phenotype…
Researchers from the UNSW School of Biotechnology and Biomolecular Sciences and School of Medical Sciences and the Neuroscience Research Australia have uncovered a new molecular mechanism responsible for the loss of synapses, a key event in the early pathogenesis of Alzheimer’s disease. The research paper, entitled “Aβ-dependent reduction of…
It is widely accepted that exercise is good for your health, but can it even increase brain cells? That is the conclusion from several new reports published in the first issue of the journal Brain Plasticity. Overall, the publications presented several pieces of compelling evidence revealing that exercise benefits the brain,…
Amyloid plaques impair astrocyte function to regulate brain vessels’ blood flow in Alzheimer’s disease. These are the findings from a study entitled “Vascular amyloidosis impairs the gliovascular unit in a mouse model of Alzheimer’s disease,” published in the journal Brain. In this study, the researchers investigated the role of…
University of California researchers recently showed that the targeting of a neurotransmitter involved in stress responses significantly reduced cellular and tissue damage while preventing the onset of cognitive impairment in a transgenic mice model of Alzheimer’s disease. The study, entitled “Corticotropin-releasing factor receptor-1 antagonism mitigates beta amyloid pathology…
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